If the basic steps don't work, consider these more specific solutions:
Open Steam, go to your Library, right-click Resident Evil 6 , select , and click Browse local files . resident evil 6 fatal error failed open file
A corrupted local save profile or a bugged Steam cache can trick the engine into searching for a file index that does not exist. Completely close and the game. If the basic steps don't work, consider these
This is the most effective fix for missing or corrupted files. Open Steam and go to your Library . Right-click on Resident Evil 6 and select Properties . If the basic steps don't work
Are you seeing a (like a .sngw or .arc file) in your error message? How to FIX Resident Evil 6 All Errors
Turn off Fluffy Mod Manager or any other injector tool.